EPA TSCA Chemical Substance Inventory

EPA TSCA Chemical Substance Inventory is the authoritative public list of every chemical substance manufactured (including imported) or processed in US commerce under section 8(b) of the Toxic Substances Control Act — and it is the regulatory backbone of the Specialty Chemicals vertical. The July 2026 edition carries 70,774 non-confidential listings: organic and inorganic chemicals, polymers, and UVCB substances whose composition resists a single formula. A listing marks a substance as an existing chemical; anything absent from the list is new and requires a Premanufacture Notice before manufacture, which makes the inventory the first checkpoint in any formulation, sourcing or portfolio decision.

The exclusions sharpen the picture: pesticides, drugs, foods, cosmetics, tobacco, nuclear materials and munitions all sit outside TSCA, governed by their own statutes, so knowing the boundary is as useful as knowing the contents. Get a sample of this dataset to see real rows alongside their complete field dictionary.

Four rows straight from the inventory — three from the main non-confidential table, one from the companion table that carries confidential entries:

EPA TSCA CHEMICAL SUBSTANCE INVENTORY — JULY 2026, NON-CONFIDENTIAL LISTINGS
| ID | CASRN   | ChemName                                              | FLAG | ACTIVITY |
| -- | ------- | ----------------------------------------------------- | ---- | -------- |
| 1  | 50-00-0 | Formaldehyde                                           |      | ACTIVE   |
| 2  | 50-01-1 | Guanidine, hydrochloride (1:1)                         |      | ACTIVE   |
| 4  | 50-07-7 | Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, ...  | S    | ACTIVE   |

COMPANION TABLE — CONFIDENTIAL ENTRIES, KEYED BY ACCESSION NUMBER
| ID | PMNNO   | ACCNO  | GenericName                                    | FLAG   | ACTIVITY |
| -- | ------- | ------ | ---------------------------------------------- | ------ | -------- |
| 1  | P000005 | 232689 | Polymeric MDI based polyurethane (PROVISIONAL) | PMN; S | ACTIVE   |

The texture is the story. Simple molecules appear as a CAS Registry Number and a clean CA index name. Complex structures arrive half-truncated, identified by a definitional text string rather than a formula. And confidential substances surface only as generic names pinned to accession numbers — 15,967 of them — so a screening exercise must reconcile against placeholders as well as named chemistry. Of the full list, 36,522 substances are active in US commerce against 34,252 inactive.

Ten columns ride along with every non-confidential listing. CASRN and casregno give the registry number with and without dashes; ChemName holds the preferred CA index name; DEF carries the chemical substance definition that pins down Class 2 substances whose index name alone is too vague. UVCB flags unknown or variable composition, FLAG stacks up EPA's regulatory action codes, and ACTIVITY settles the active-versus-inactive question that most screens start from.

Records in the confidential companion table swap the chemical identity for a different set of identifiers — premanufacture notice number, EPA accession number and generic name. Those ship as additional fields available on request, mapped onto the same dictionary.

• Geography: the United States — substances in US commerce, imports included, wherever they were made.
• Temporal: the July 2026 snapshot is the current edition of a list first published in 1979, reissued roughly every six months; the underlying master inventory moves almost daily as Notices of Commencement arrive, about 400 a year.
• Granularity: one row per non-confidential chemical substance listing — 70,774 of them — plus 15,967 companion records for confidential entries keyed on accession number. No volumes, no companies: this is the universe of substances, not who makes how much of them.

Your call, not ours: API, files, or your warehouse. Daily, weekly, or hourly.

Every delivery ships the complete field dictionary above, the sample rows, and the coverage profile — mapped and ready, with no integration archaeology on your side.

Ranked by relevance scores from Datadory's persona research:

1. Journalists, academics & students — cite the government's own boundary of US commercial chemistry: 70,774 listed substances, 36,522 of them active, with agency provenance behind every row.
2. Data scientists & ML engineers — join CAS Registry Numbers into hazard, exposure or property models; the UVCB flag and DEF definitions tell you which substances need fuzzy rather than exact matching.
3. Market researchers & consultants — scope addressable formulation space and screen competitor portfolios against the active/inactive split before sizing a specialty segment.
4. Developers & data-product builders — wire a stable, ten-field substance registry into compliance checkers and PLM tools, with regulatory flags arriving as structured codes rather than prose.

Notes and adjacent reading:

• ECHA CHEM - EU Chemicals Regulatory Database (REACH & C&L) — the European mirror: REACH dossiers and C&L classifications for well over 100,000 EEA substances. Together they bracket transatlantic regulatory exposure.
• US Economic Census — Chemical Manufacturing (NAICS 325) — 14,961 establishments and $901.0 billion in shipments; the economic denominator above the substance list.
• vs US Economic Census Chemical Manufacturing — where the regulatory universe and the industrial economy meet and diverge.
• OECD eChemPortal — federated hazard records for roughly 800,000 substances across 34 government databases, reachable from the same CAS keys.
• Kaggle — 426k PubChem Molecules for LogP Prediction — computed molecular descriptors to attach to named substances.

Browse the whole vertical on the Specialty Chemicals industry hub or the ranked shortlist of the best specialty chemicals datasets. Background reading: TSCA Chemical Substance Inventory, CAS Registry Number and REACH regulation.